Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_00415T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationCMGC/CDK protein kinase
Gene SymbolCDC2801
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNA04030 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
CMGC302.43.6e-90
Microbial Kinome Result
PredictionScoreE-value
ePK259.12e-77
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K08818 KEGG 2e-175 583.8
Amino Acid SequenceMDSEDRNTASSQPSLTSSSRHQAPLAGNQGSPSLVSVGTKRSLLDGIAHNGESPSSPAPISIKRRLVRPRKIRQSHGDVSPPASVGLQMPKETLAVAESEPLKPALSPSPPLQSSKPPSRLPSPSISTPSFADAPLPPPPRSRFAPPRSAHPPLVSCRSVYNYTRLNHIEEGTYGVVFRARCNDTGEIYALKKLKLDEEKQGFPITSLREVMALMIAGGHENVVGIREIVVGDTLNQVFIVMPFIEHDLKTLLADMPHPFLQSEVKTIMLQLLSAVAHCHANWILHRDLKTSNLLMNNRGQIKVADFGLARKFGDPLGEMTQLVVTLWYRSPELLLGGKEYTTAVDIWSIGCIFAELMQGEPLFPGRGEIDQINRIFQLLGRPNDESWPGYSALPLVQKINTVGPMFSTLRQKFKHLTYEGHNLLSSLLCYDPERRITAEEALKHPYFSEHPLPKHPDLFSSFPSQAAGERKHKSLVSPSAPVREDRMAKDSLADLDSFV
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 609
B YPD 30°C, concentration: 5x10^7 cells/ml 1274
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 1313
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 1212
E YPD 37°C, concentration: 5x10^7 cells/ml 1324
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 760
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_00415 5' flanking region primer 1CGCATTCTGGACAAAAGC
L2CNAG_00415 5' flanking region primer 2TCACTGGCCGTCGTTTTACTTTGCCGTATCTTCCTGG
R1CNAG_00415 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGTGATGTATCTAATCCCTCCG
R2CNAG_00415 3' flanking region primer 2AGATTCGGTGCTTTGTGTC
SOCNAG_00415 diagnostic screening primer, pairing with B79TTGGTCTGGGAACCTTTAC
POCNAG_00415 Southern blot probe primerAATGTGCTACTGCCGACAG
STMNAT#191 STM primerATATGGATGTTTTTAGCGAG
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_00415T0
Mating Data
Growth phenotype for CNAG_00415T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_00415T0
Urease
Urease phenotype for CNAG_00415T0
Melanin
Melanin phenotype for CNAG_00415T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_00415T0
Oxidative Stress
Oxidative stress phenotype for CNAG_00415T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_00415T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_00415T0
ER Stress
ER stress phenotype for CNAG_00415T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_00415T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_00415T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_00415T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_00415T0