Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_03258T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationAGC protein kinase
Gene SymbolTPK202A
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNG03180 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
AGC138.67e-41
Microbial Kinome Result
PredictionScoreE-value
ePK176.02.2e-52
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K08286 KEGG 4.1e-67 225.4
Amino Acid SequenceMDSTPYSIRYRILSDLLDSNIALAYDNAFIVDGESSTCLAEDEKAAVLDTVLLRSWNGETSCLDSVTFNILERNRLKHDDFDIIGCLGEGQFGVVEAVRFKMSGQVFAMKTIEKTTAKRAGRLLSLSLERHVHRLSSSSSLSPCPKLVAAFQTELSLHLIITYAECGSLWNRMCALFSDTKYPGCMPEEEIQWWGAQMVNAVGWLHSHNIVHRDIKPHNFLIKSDHHLQITDFGSAAPLYFTLPDEPLCVPWQFCVQPVGTPDYLAPEVLILAEQAVIESEQVHQTSDSHIPQHSEKKGYNASIDWWSLGSTLYEMATGKPPFFAETIHETYEKLITFRSDNLSFPTYLSSELISLLKDLINVPVKRLSTATMIQKSPFFQPTGWIDNCPKILCPPLISHDMLDNEQLQTNLQQSIQEDKFTFSHFFDFSNTSSVHLTPVSPSSSAPPVWSQWVGWSFHPDPDSLEVPSAADNSSGNAFMTPVRNKLTTCPFTPGIMNQPLAPLLPSTRSTKKQAFQELLHCVQMSAKKHMMRYNSQSAHSTSPCMTPVARGQMKTKSFTKDTSCVSLLSDPGMVLVETGASHQWLQERHDVLCGQLHHLDQQLFKLQKLLKC
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 4302
B YPD 30°C, concentration: 5x10^7 cells/ml 4254
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 4070
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 4568
E YPD 37°C, concentration: 5x10^7 cells/ml 4812
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 3852
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_03258 5' flanking region primer 1AGGGACTGAATCCAAAGGG
L2CNAG_03258 5' flanking region primer 2TCACTGGCCGTCGTTTTACTTCTCGTCTTCGGCAAGGCAAGTG
R1CNAG_03258 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGAAGGACAAGGGCTAATGG
R2CNAG_03258 3' flanking region primer 2AAGGCTGGACTTTGTTGGGGAC
SOCNAG_03258 diagnostic screening primer, pairing with B79GATTGCGAAGATGTGAACTC
POCNAG_03258 Southern blot probe primerTTTCCCTGTTGCCATCTC
STMNAT#208 STM primerTGGTCGCGGGAGATCGTGGTTT
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_03258T0
Mating Data
Growth phenotype for CNAG_03258T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_03258T0
Urease
Urease phenotype for CNAG_03258T0
Melanin
Melanin phenotype for CNAG_03258T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_03258T0
Oxidative Stress
Oxidative stress phenotype for CNAG_03258T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_03258T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_03258T0
ER Stress
ER stress phenotype for CNAG_03258T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_03258T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_03258T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_03258T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_03258T0