Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_03369T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationWee protein kinase
Gene SymbolSWE102
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNG02130 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
AGC-11.71.7e-16
Microbial Kinome Result
PredictionScoreE-value
ePK160.18.2e-48
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K03114 KEGG 5.2e-143 477.6
Amino Acid SequenceMHHTLAPAHTCPPSSAPHSPPRTTVTPLRQSSSQTCRPSTSSLPRSHKRAKSTRQSLGGRPKREASIPMLSQQLSTFSLRQDVLSEMLAQETPPTITSPFKYASHTTSASLTTPYTSTFKHHPSAEHMPAKSKSAGPKFVTQNSKGRHIEDISPTRPASEDHLADWDVSHPSSDEPDLEWLQSGEWLPPLQSKESNAQDCLQGSLQHCRDRDCSVSSMEFSGSDTSSVSLLSLARSSLEQQTRPDIVQWDENPAEIDGEQAGHSGFDARSGSSALHLPIKLNSSPSISPFITSDCHKPPNDTPPGPFDNQADFPMDSPSVFSTRSSQHARSDSRSTILPRLLLSKKSTATLREQNERSKVLGHMEDEEMMSDVEDIPSPKSPSRPKSFWDRAKFKTSRNRFDGNGFGATFGLGIELGPRRIPSVEDHNENNGLSVSLASDSSGDADLSPSRSLLANRRSSSTFAHDPANDNAPEVGPRFEAPTRPTMPRRIPTVGSILQRIPRTSSPAIPTLNSLRGKGRPPMRRGTTEPTEKPKPTLLMADAALSTPHALPFADVKPSPSVFASAGLVKKKSRFSGAEIPKFGSEPLANVKRTQSAAQYGMQPAPGPGSMQPPSPVSPIQSMSAPSIPLKGTGFMTAGSSNAHFAQQAQKTRGLRKKRSSMFKAGSSISSMEMIRGNSRGSISGVSLSPVTPTKHDGAPKVYGLTTPSPIRAPVVYPFASSNPVDLDLFSTPPSNRLNRPGALDAPIAERYRSMLAGSPNATMEAQRKPVIRASNPMLAASFKSAAQITTPARGHTSQGLSMFVGRPKLGGEGITRLETDFALVENLGNGAFSQVWKVREKKTGKVFAVKAGKPYTGAKNRLRQLEEIAILRELSLDPHPNVIQYIDSWESHSRLYILTILVDCGDLSTFLSLLSDHGGIREARVWKSLVELAEGIDHIHKHHFLHLDVKPSNILINSAGGLVVADLGMAVICGDGPDGHMLGGMSPALPERDEKGGFVWDQVETPMDDGKKSLAMVPSPIMDREVEGDREYLCPEALSEAEMIGKGADVFSLGILLLESALNVVLPSNGDAWVQLRNDDFSDLNGIYIPRPHSASSPNLNPPSDDPNMPVLSDDILTVIKGMMRSNPDRRWSLGDVWRHPVVKRVRASERGKALVEESDEWLKKVLGEEL
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 950
B YPD 30°C, concentration: 5x10^7 cells/ml 2523
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 2342
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 2530
E YPD 37°C, concentration: 5x10^7 cells/ml 3011
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 992
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_03369 5' flanking region primer 1TGCTACGCTAAGACTGGACTAC
L2CNAG_03369 5' flanking region primer 2TCACTGGCCGTCGTTTTACGGAGCGTGGTTGAAAGAAC
R1CNAG_03369 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGACGAACTTGTGCTCTCTGC
R2CNAG_03369 3' flanking region primer 2ACAGTTTCCTGACGAGAATG
SOCNAG_03369 diagnostic screening primer, pairing with B79GCCGATACATTTTGGGTAG
POCNAG_03369 Southern blot probe primerTGGATGGTGAGGAGTTGAG
STMNAT#169 STM primerACATCTATATCACTATCCCGAACC
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_03369T0
Mating Data
Growth phenotype for CNAG_03369T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_03369T0
Urease
Urease phenotype for CNAG_03369T0
Melanin
Melanin phenotype for CNAG_03369T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_03369T0
Oxidative Stress
Oxidative stress phenotype for CNAG_03369T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_03369T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_03369T0
ER Stress
ER stress phenotype for CNAG_03369T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_03369T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_03369T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_03369T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_03369T0