Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_03843T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationNAK protein kinase
Gene SymbolARK1
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNB03330 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
CAMK-22.20.000000000000053
Microbial Kinome Result
PredictionScoreE-value
ePK120.51.6e-36
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K08853 KEGG 1.4e-154 515
Amino Acid SequenceMYAPAPPPGQRHSPFPTPPPTVPQKHQYPAPIGSPYYPQQQHAPPPQRHKGTLHPGQIVNVDQCHVRIERYLSEGGYAHVYLTSSDRPVYPPSRGTEKKGRWGEKGYTQHCLKRIAFQDDSVWVDVKKEIEVMKSLPPNSHLVQYLGSSHTRSPAGQHEVFILMEFCAGGGIIDLLNKRLRDRLKEIEILNIFTDVCEAVAAMHSLRQPLLHRDLKIENVLSQPVNIPPTPQRPTSLIFKLCDFGSTTFPADRPPQTKLEADALAMDLNRHTTLQYRSPEMVEPMLGLPVGLPSDVWALGCLLYKLCYYTTPFEEHGPLAIVNAKYTFPPMPQYSPRLQHLIASMLVEHPARRPTVFEVLRVAHEMSGTRPEVDYPITLKSLPIPAQPRPTKPQLHSSNNLLDFTGSPSSMGKSPSLQPSLASTVQPQRRGRPTRDTTRESPRPTGQTQARWQQSPVQAQQKPQMTSSSANTRAPSRLHITGENAPLSSGNAPLSTTSPPPVDAFGMPIVPSTKPTGTGFGDSFGAGASVVRPTGTTGSSQPSQSRYGSNFIKRPTGFGDSFGSGITRTPSISSRSSTHPPVKRVPSGAIPVSSKQHSPIVSQKSPEPSSVPEGDLSFESRFPSIETLNSEATLSPPEKLVSPVVSPPPSDNANTPSSTTLSAVSNFGGLRPRPSVTSRPSMSSNLTGGRMRIPDEDGQAMPGEVKKHVQPRSTQVTGTAFRGQVSGLAPNLAQGGGREGRAYREENDKQQEEEVMKKENGEEEEGEKRDVSEKKIDKRTPEDLMGSEETGSLQIPSIVPVRSISPASATSAMSATSAKNRGPPLSIDATKTGGTNILSDNWSPLEEMRKRDAAGRAEAAVQKKKAEAEDSSDEEGPEDPGMILRSPTAQPAAAVSGIVSPEPTKSASLPAPASPSTQQVSQRIPSRERARPQSMFLPSTSSNSVPSRSSVLSPPLRNEPSPLPSSQSPPKSSIPSSSRPSQGHQKKDSINGMVSKYESLSVGKPDEDTGKRPVRQHVPKPNEGTNALANKPSVARKPVGLRKPSADLNHYSSVDVAQNDAASPTKPRAASKPSTLRQDPGVGTGYIRPGMSASPSVRPNPVVSTSFNSNPDRRGKEDEVVEKGSLKSAGSSPEKQQPVNLLIQRWNKGEVNNASANAAKLKKGGYI
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 4025
B YPD 30°C, concentration: 5x10^7 cells/ml 3708
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 4054
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 2481
E YPD 37°C, concentration: 5x10^7 cells/ml 3200
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 4219
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_03843 5' flanking region primer 1CAATAGGCGTGAACAAGC
L2CNAG_03843 5' flanking region primer 2TCACTGGCCGTCGTTTTACGGGATACTGGTGTTTTTGG
R1CNAG_03843 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGAGGTCAACAATGCGTCAG
R2CNAG_03843 3' flanking region primer 2GAAAGGAAGGAGCGAAAG
SOCNAG_03843 diagnostic screening primer, pairing with B79ATAGAGCGGGAGGAAATG
POCNAG_03843 Southern blot probe primerTGGGTGGGAGTGATTTCTG
STMNAT#43 STM primerCCAGCTACCAATCACGCTAC
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_03843T0
Mating Data
Growth phenotype for CNAG_03843T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_03843T0
Urease
Urease phenotype for CNAG_03843T0
Melanin
Melanin phenotype for CNAG_03843T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_03843T0
Oxidative Stress
Oxidative stress phenotype for CNAG_03843T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_03843T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_03843T0
ER Stress
ER stress phenotype for CNAG_03843T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_03843T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_03843T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_03843T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_03843T0