Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_05005T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationULK/ULK protein kinase
Gene SymbolATG1
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNL06100 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
CAMK121.11.4e-35
Microbial Kinome Result
PredictionScoreE-value
ePK250.11.1e-74
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K08269 KEGG 1e-167 557.9
Pfam Annotation
Pfam AccessionE-valueScore
PF12063 Pfam 1e-28 97.5
PF21127 Pfam 8.1e-19 65.4
Amino Acid SequenceMPDSNSQGAREKESGHHRSHKERIGNYVVGAEIGRGSFATVYKGYRSKTRVPIAIKAVSRQKLTSKLLENLESEINILKVINHRNIVALTDCFKNDTHIYLVMEYCSGSDLSVYIKQRGNISTLDFVPKAGSSMALLPTNEEGKIYWPHPPTGGLDERVTRSFLGQLAQAIKFLRAQDLMHRDIKPQNLLLQPATETEVAEGHPYGIPVLKVADFGFARILPAAAMAETLCGSPLYMAPEILRYEKYDAKADLWSVGAVLFEMSVGRPPFRANNHVELLRRIEKSNDKIVFPDEKERDSKSSDETSIPVSSDIKALIRALLKRKPSDRMGFDDFFNCGVWDGHMTESTEEESLSLDVSTDSSTGLGESDRIRQMVASAEQSKDRLLPTRAPQPLAADAALNPQPAVSISRDTSEGRSRLSTPPSRPTPTRRSTPKYYVGDAPPSEPTAIIPPSPSSAPTPTPAPEPGLTTQQSPTSRANPRPIITAASSAQRRMSGKGDAREASSVEEAAPVTPPFTGPSPTMARPSRGINEGSPLATAPPITMGPDGRLERSSALEGSTSGVGTDYVVVEKQTVEINALADELDQASKRPMIRRSSRGSVVSRPVSSFKPISPNITKNDPTLGQVSYSPPFALSSTPPFAMQVPRHTSGGNPFPRNPSIPSSLNAFPPTTISASPSYGQDAAARFGVSPGSLQTGALARALTNTAIRLIGTSANTAATAIARATSKRRPNIVRVSDMDAAEDELLRIVEDLARKAFVLFELADERLLAQTQLAQTARTSSTPTGLTGTTPPFSMQAAAAAQAGSRRKSSSSSMNSEVWILRQQEAAANDAVVLYMKSLAFIVKAMDKVKRYWKSRTDVSDGYVASQELNEMGQWLRARFNETFEKAEWARTQAGDTLLFPDWLVHDKARDTSRQAAVAELQGDLTTAEQGYETSLWLLQALLDESVYENGSIPDEDKVAYERLMVPIKTRLDALRKKLAESSGMTTR
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 4233
B YPD 30°C, concentration: 5x10^7 cells/ml 2277
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 3098
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 1282
E YPD 37°C, concentration: 5x10^7 cells/ml 1471
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 4971
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_05005 5' flanking region primer 1CGCAGAACAGTCCTACACAAC
L2CNAG_05005 5' flanking region primer 2TCACTGGCCGTCGTTTTACCTCCTTGCGAGTTTGAGTC
R1CNAG_05005 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGCCCTGAGAAAAAAGTTGGC
R2CNAG_05005 3' flanking region primer 2CGGGAGGAAAACTTGTTC
SOCNAG_05005 diagnostic screening primer, pairing with B79GATTCACACAAGAGAGCGG
POCNAG_05005 Southern blot probe primerTTCCCCTCCTCATTTGTC
STMNAT#288 STM primerCTATCCAACTAGACCTCTAGCTAC
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_05005T0
Mating Data
Growth phenotype for CNAG_05005T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_05005T0
Urease
Urease phenotype for CNAG_05005T0
Melanin
Melanin phenotype for CNAG_05005T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_05005T0
Oxidative Stress
Oxidative stress phenotype for CNAG_05005T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_05005T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_05005T0
ER Stress
ER stress phenotype for CNAG_05005T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_05005T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_05005T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_05005T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_05005T0