Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_05590T0
SpeciesCryptococcus neoformans var. grubii H99
Gene Annotationhypothetical protein
Gene SymbolTCO2
Kinase SuperfamilyHomodimeric domain of signal transducing histidine kinase
Kinase FamilyHomodimeric domain of signal transducing histidine kinase
KEGG Linkout KEGG::CNH02350 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction N/A
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K20974 KEGG 5.6e-186 332.3
K20974 KEGG 5.6e-186 282.6
Pfam Annotation
Pfam AccessionE-valueScore
PF00072 Pfam 2.3e-44 85.8
PF02518 Pfam 3e-47 77.3
PF02518 Pfam 3e-47 77.1
Amino Acid SequenceMILGTDIDLSSIPTAFLEAYPFPAVVFVIDSPPSPRPRLHSRNTDTTIRRTDGQISPLTGPPVQQFASAPVVWGNQRWHELAQGKTIAECVDVASQNKLQTWVENDTGDKSESLALDLKVPQGVTLHLAKTILPLSPPSSSQSLCILISQYIDKPESFAPPISSGDILFSSLSRLSQTFSRSSSFSSNPRKSIDVPASLSEHRGSATSTSSNLRSSIDLTSPNSQPSPLNREQSTYFTHGSATREERPSVRRRRSPPISMTRPKPLESHAQECWDLVENFDWSKTALGPREQWMDALDPVLAITFESRTADCAWLGPDLELVYNKAYQELVDHPNAFGKPARQVWATNWDYLEPLVKRCLSGTPVYKDNDPLFWRRYGNGRLLEHYHTWRYVPITGKDGSVLGIFNQSIEVTDSVLLERRMGTTRELSEHMSFIRTTEDFFSSVADVFSQNPTDIPFALCYRVRQVDTDGTFVHLDVSLQSSVGVPEGHPSAPDQIPVSFLNGNPYPSNVERSFSPAFSIVSIHSSSSHRVCHVSEDTTQWPIAKALQRRQCVIIEECSQLIEGYPIRRWDGLPFSAIVVPICSEGSPEIPDAVVILGLNVRRCFDHEYDSWIHSIRSQLSSALVMVKAREAEQKMVEESARMEKAKVAWFRGAAHDLRSPLTLVAGPLADVLDSDLNSSQRTALTVAQRNLDRLVRLVNALMDFSRVEAGRMEGRFVPTNLSQFVTQLAALFKPAIERLGLEYVLDVQPSEELVFIDPVLFETVVSNLIGNALKYTETGSITVRVQYTDYAEVSVIDTGVGIPKNELALVTEWFHRASTAIHSGTQGTGLGLALAKELLKLHKGELLVESQTANESGGPHGSIFTAKIPLDFKPSPSAHIIPSVESHKTFGKYSKAVADEAMRWVGDSDAASEAYDMSSGTGVSSAGSGSGNTTTFGPKFADAFLFDKNDIVLIVEDNVDMREYIRQLFAPYCTVLEASNGEQAYNMATQNPPNLILSDVLMPKLSGMELLQRIRSHPDTRIVPMVLISAIAGDESRVEALLNGADDYLAKPFKPKELIARVHLHMQVGKKRAKLEALYAQRETELTALSDYCPIGIFRGDKYGHIVYANAAWRAQSGLLVGDPNDWASYVHPDSKAQLLEQWNQWLRGDLKEFRAAWRWSNGIPVRSILVRLDDVKEGFSGLIGCVVDVSHEERRLIEAEERRKEAEESKHQQELLIDLTSHEIRTPVSAILQCSDLVKENLVALKDQLRGAGPKGFVPSQELLADLEQDVEALESIYQCGLVQERIAGDVLSLARIQLDMLSLHDIDVNLRREGRKVSSIFASEAKMKDIDLQLEFGPTIEQSKVLAIKTDPVRLGQVVTNLISNAIRFTSSSDVRKITIQYDVSFVPPADDSCALPSSVGLPDILPVKENTPLWLFVSVTDSGPGMTEQELSVLFQRFAQGNKMIHTKYGGSGLGLFICRKITELLGGRIEVLSQVGHGSVFRFFIKTRAVAPPSAIAALVESSPLKPVSATSPSSSLAMSRSSSRSTNVTTPIEGGGTEHVLIVEDNLINQTVLKRQLVKAGLSCNVASNGLEALNVIREVHRQHRRGGPNRKRLFDVVLMDLEMPVMDGITAVREIRQSEAAGTLGRNMVIALTGNARQGQIDHALASGFDDVVIKPYILVDLLNKIKSMKVRKLELETAKAQEE
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 71198
B YPD 30°C, concentration: 5x10^7 cells/ml 26914
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 25122
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 32295
E YPD 37°C, concentration: 5x10^7 cells/ml 17891
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 27820
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_05590 5' flanking region primer 1CAAAACTGGAAGAAGCGAAG
L2CNAG_05590 5' flanking region primer 2CTGGCCGTCGTTTTACTTGCCAGATGAAGAGTCACGCC
R1CNAG_05590 3' flanking region primer 1GTCATAGCTGTTTCCTGTCCCATCCTCTGTGATTCCC
R2CNAG_05590 3' flanking region primer 2ATTGTGGAGTGGTGGAGTGGAC
SOCNAG_05590 diagnostic screening primer, pairing with B79TGAGGAGGAAAGTTTTAGCG
PO1CNAG_05590 Southern blot probe primer 1GTTACCGATTCTGGACCTG
PO2CNAG_05590 Southern blot probe primer 2TGCTTCACCCTTTCAGTCTC
STMNAT#116 STM primerGCACCCAAGAGCTCCATCTC
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_05590T0
Mating Data
Growth phenotype for CNAG_05590T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_05590T0
Urease
Urease phenotype for CNAG_05590T0
Melanin
Melanin phenotype for CNAG_05590T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_05590T0
Oxidative Stress
Oxidative stress phenotype for CNAG_05590T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_05590T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_05590T0
ER Stress
ER stress phenotype for CNAG_05590T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_05590T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_05590T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_05590T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_05590T0