Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_06568T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationRAN protein kinase
Gene SymbolSKS1
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNF04490 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
CAMK78.11.1e-22
Microbial Kinome Result
PredictionScoreE-value
ePK190.59.7e-57
Functional Annotation N/A
Amino Acid SequenceMSTSANPLHVAGGSPQFIDGGYIELVAVIGTGAYGVVYLAVDSRYPQPVYRAIKCMRRSGLDERQKHFQRREMGLHRLASGHPSIITMDRIFEEGDYIYVVMDYGDEGDLFSMITDKKRYVGDNELIRNVFLQLLDGVTWMHSLGISHRDIKPENIVCSQDGTRVRICDFGLATSEERSSEFGCGSTFYIAPECLGDWFPENKTYPTRSGDIWSLGVILVNLVCGRNPWRIASPSDESFNSYLADPHFLRKILPVSDECLYILTQIFTVHPEERITLPVLRQLVSKVETFSMSVDELRHAHISAQQKIAATQPPVLLSLPKEDDSWSEQEELFAYDDDLETPSLRSDSDSPRYPLCLSPTTSSNGESLPPTPNLIPDECITFAHQPQSPQFWEYVPKATFEYEHNQRSTDVHIKGSSLFTYNSAPTTYAQ
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 1506
B YPD 30°C, concentration: 5x10^7 cells/ml 921
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 694
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 963
E YPD 37°C, concentration: 5x10^7 cells/ml 1504
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 4048
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_06568 5' flanking region primer 1AATAAGGTCTCCAGCCTCG
L2CNAG_06568 5' flanking region primer 2TCACTGGCCGTCGTTTTACCCACCATCAATGAACTGC
R1CNAG_06568 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGAACGACCTGTTGATGACG
R2CNAG_06568 3' flanking region primer 2CAAGTTGAATGCTGGGAG
SOCNAG_06568 diagnostic screening primer, pairing with B79AGCAAGTGGGCAAAGAAGC
POCNAG_06568 Southern blot probe primerAACCGAAGTCACAGATGCG
STMNAT#211 STM primerGCGGTCGCTTTATAGCGATT
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_06568T0
Mating Data
Growth phenotype for CNAG_06568T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_06568T0
Urease
Urease phenotype for CNAG_06568T0
Melanin
Melanin phenotype for CNAG_06568T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_06568T0
Oxidative Stress
Oxidative stress phenotype for CNAG_06568T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_06568T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_06568T0
ER Stress
ER stress phenotype for CNAG_06568T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_06568T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_06568T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_06568T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_06568T0