Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_06671T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationTKL protein kinase
Gene SymbolYKL1
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNF03480 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
TKL157.21.9e-46
Microbial Kinome Result
PredictionScoreE-value
ePK182.32.7e-54
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K04423 KEGG 3e-80 269.9
Pfam Annotation
Pfam AccessionE-valueScore
PF07714 Pfam 8.5e-46 154.7
Amino Acid SequenceMDRLQRTRSQHFVSSPRKTASPLIARHTLYHRHPPKKRRLGVTTFVASHNEAGQGYTNELEDDLEKAIMKRGESSSAPAGRTSRSRSQSRPVRQKSNGKVSADSLSNGQDDEDVPSPKKRKRSRAGSLSTEDSWVETTEDEWEPDFIAEGDRNLIHYAPSTALHRLRKAELVRLWKVAGIWDSEDIPDDMNEDETIGDMGKKELVDGLIAARKHQTRRLISPLPSSPNRLIRRQSTLSPIPATPPPSSPLVESSSPDVTPKPRPRTRSRVRLETPIVRRQPRPSRPTRTLTKRHTKSEARSRRVRAQLAKKVNGKSENGDESELTELSDSDDDVNESTPIVKRLRPRGVGGRKSFMKEPSTDITDFEDDAEEADAEATEVEEEPPHPKGRKLRSISISQASLSKHGSDIDMAPVSGQRSPKSLPTRGAKKKAIQRMQGGESGTEDEDMEMDEDKDIGVEEGTPMPQPATPPRKGRASRLSTPKLDEDSAMVGSPTPSVATETEAATPRPVHTTRSGKAFGAIQNRRRQLLQEARNDPDMDEEDESDEEDGEPEPDIDLSEATVASLIRLLRDELVQMCEARGIEVGGTKPQLAKALLEWRDEQKGSYPSSTSTARPSPPRTAMPRRKSKSKSKSRTKSKFKSNKHVPAIGTAVHAPGKPTPVLLRSHVHANDPETPPLSKGEEGDVEEEKKGTEAELNLDLQELGLEDSVIKPSHLTKLEKIGSGGFKDVYVGKFRGRKVAISEFRSHLSEMDIRELKLLAEFSHPNIVRFRGICIPEDSTHVPCMLVSELCENGDLFDYIRNVPCPTLKRLLSLMLDIARGLEYLHTRKPSIIHRDCKSSNILINRSGVAKVGDFGLARVKNSTRSMIRSLVGTVNWQAPELWHPTPRYDYKVDVFSAGMVYWEMMSGWIGEKKYPWEGHNEHYIYDAVGTKHRRPPVTGMRKHWGSEPVNLMERMWHQDPAERPTMTDVVHDLESMLAELK
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 4290
B YPD 30°C, concentration: 5x10^7 cells/ml 4532
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 4717
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 3697
E YPD 37°C, concentration: 5x10^7 cells/ml 4129
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 5304
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_06671 5' flanking region primer 1CCGACCTACTGATTCGTCTAC
L2CNAG_06671 5' flanking region primer 2TCACTGGCCGTCGTTTTACCTCGCCCCTTTTCATAATG
R1CNAG_06671 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGGTCCAATCAACAACAGCG
R2CNAG_06671 3' flanking region primer 2TGCGGAGGAGATTACCATAC
SOCNAG_06671 diagnostic screening primer, pairing with B79TTCGCCTTTGAAGTTCCC
POCNAG_06671 Southern blot probe primerGGAAAGTGTAGATTGTCGGC
STMNAT#123 STM primerCTATCGACCAACCAACACAG
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_06671T0
Mating Data
Growth phenotype for CNAG_06671T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_06671T0
Urease
Urease phenotype for CNAG_06671T0
Melanin
Melanin phenotype for CNAG_06671T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_06671T0
Oxidative Stress
Oxidative stress phenotype for CNAG_06671T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_06671T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_06671T0
ER Stress
ER stress phenotype for CNAG_06671T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_06671T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_06671T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_06671T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_06671T0