Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_06809T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationIKS protein kinase
Gene SymbolIKS1
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CND05660 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
TKL19.20.0000000000014
Microbial Kinome Result
PredictionScoreE-value
ePK150.25.5e-45
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K16194 KEGG 7.8e-40 64.3
Amino Acid SequenceMMDIEDPSRDMAGAGELEQDWRPIGHTSNQLVLYHPASHALRVRIQPPSSPRSTFPSNIVRANDALKRRSPDLATRPLCLLCRQPVSRNGLGEVAAISGMDSYFQTLEHVHSESESFSEGMGIDNLLNAPQMDTSNEENSSATGYYVRFFKEVRKLGMGAEGSVYLAVHHIEGDTLGTYAVKKIAVGESKEYLHKILHEVKLLEVLRHTNIIPYYHAWIDTTRFSDLAPPVLALHVLMMYASGGNLDSLLLSRSHSTGFATGLSADDIADAESIDKLPKEERIKAFKRRRQSAKTEWANNRRSFSGGMGASRAENRGVLLLSFEEIVQLFGDIIEGLSFLHSNSILHLDLKCSNVLLHWEEGKLVPKAMLSDFGTSEEMLRGQRERTGHTGTMEYMAPETLVQDSEGRFRPSDSHADMWSLGMILYKMMFLKLPYEECDNYDVLRAQIISYKGFLPDGSLLQNLQRRHIPQRFVFLLKKLLDIHPEKRPSAEKTRSVLADIKHHSNQNEDYSSAIVGQTLASLENLSYPNRGICRRNSVVVNDGHLNADATASNNVLLPFFPSPKKKLLPSFIDGHERAMTCLAGPAVRLALLFGKLVSIQPSISGVRLPPAVAVILILLALTDLAHQGSLLWSLTCLIAHCAAVLNFSSHEV
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 4632
B YPD 30°C, concentration: 5x10^7 cells/ml 2773
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 2939
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 3544
E YPD 37°C, concentration: 5x10^7 cells/ml 3316
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 3890
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_06809 5' flanking region primer 1TGGAAGAGGATGAAAGACC
L2CNAG_06809 5' flanking region primer 2TCACTGGCCGTCGTTTTACACAACTAAAGGCACAAGGG
R1CNAG_06809 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGATGAGCGAGCAATGACCTGC
R2CNAG_06809 3' flanking region primer 2CAGAACGGTCTTTTGCTTC
SOCNAG_06809 diagnostic screening primer, pairing with B79TACAGTATCGCTGGTTGCC
POCNAG_06809 Southern blot probe primerAGCGAGACTGGAATGTGGAG
STMNAT#116 STM primerGCACCCAAGAGCTCCATCTC
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_06809T0
Mating Data
Growth phenotype for CNAG_06809T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_06809T0
Urease
Urease phenotype for CNAG_06809T0
Melanin
Melanin phenotype for CNAG_06809T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_06809T0
Oxidative Stress
Oxidative stress phenotype for CNAG_06809T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_06809T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_06809T0
ER Stress
ER stress phenotype for CNAG_06809T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_06809T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_06809T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_06809T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_06809T0