Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_07580T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationCAMK protein kinase
Gene SymbolTRM7
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNK00420 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
CAMK70.32.6e-20
Microbial Kinome Result
PredictionScoreE-value
ePK184.08.7e-55
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K08286 KEGG 1.2e-67 227.1
K14864 KEGG 1.7e-110 367.6
Pfam Annotation
Pfam AccessionE-valueScore
PF01728 Pfam 3.4e-43 145.2
Amino Acid SequenceMPTSKSSIDHRDVYYRKGKSAGYRARSAYKLLHLDEEFDLFTNVRTAVDLCAAPGSWSQVLGQKLKPKSKQGGEGTRVVSCDLQPMAPLPNITTLQTDITLPSTIPLVLDALGGRKADLVVCDGAPDVTGVHDLDAYLHSQLLLAALTLSLTLMAPGATLIFKIFLSPLDPHAEFLASQLRCFFSSPFPEDNDEEENEFGQYGEFEEEAESAGQEGEGEKKRNVGKQGYDPQGRRGGVWVRKPRSSRQGSAEAFIVCRNFSPSALPLPPTFSPSALDKLRTTTGTLTLDSLSSLVPQDEDGSEETQRFKGSEQQVKQQWQRWEMIKGYVGGGDLSSSSSSSFIPSLHPVSPPSLPAQSPKTTLSSPPKLHLPIPTTPPNLVHHILRTPELVPPHSATASPKALQPQPTPVDEPPEYFSPTRAHARALFLSPTKIKEHRQTQGQGQGQGGGGTSRQSSLDSLTPNPSPVGDVDPTRPWTSSSLPSSTLPPAPTFVPPTITASSQEKTSLNVPLRLHSSSTSSAVSDGGRPQTPATLGVITPALASPALSSSSKTDLFFSASSAELPTPPRALSPAAALGKGPLSASASASSLSLDVGGDERARSTTMPSSSFPSASTAASWTESGIPPVKLRLPTRKERFRETDIPAEMKDKMDADRGRGGWGAPLEMGFGAGFEEISTSRLRSISNPLAPPSAHTFSPTPPAPPPVALPFTTQISRNDGDSRPEFARQSSLTPTVVSPQTPRAGFFPFTNAHTKANAVLSSSSPSAGGDTAPPPPWKLRRKESQQLEREHRQAGVDESVKAGDVIEPCLPSANADDSGHEKEKRKERVSGGGGGWRLVKKMGEGAFSAVWSAVPAGSTPSSSTPTHAPTATNILVALKLLTHPLPDPRTRIAFLREASVLRHISHPSIVGYIDDFSTERHDVLVLEAAGGGELFELMSDEENRRRMILPAPAPGSEPVAGSEETEIGWDKDGEGFVRRVFSELVKAVGWLHEVGVVHRDIKLENILFTTNPFLLPPTSTSSIPLHLLPPPCEPLIKLTDFGLSRFISPASPLLYTRCGSESFAAPEIIMGKPYDGRETDAWALGVVLYGLIIGELPFDREESMMLPERIATPGGGNSERERGRKKMHRIAKGEYTWPSPEPALSQDIPGAYAPGTATPSARAVVSSLLERNPSKRAKPSDLWGYEWMLGPGGVPRPVEGAGTPQQEGVEKDKGREASGRGRRRVLDGFLVEEEGIEDVAMTEH
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 1742
B YPD 30°C, concentration: 5x10^7 cells/ml 2238
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 2279
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 1933
E YPD 37°C, concentration: 5x10^7 cells/ml 2306
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 2338
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_07580 5' flanking region primer 1GGTGGAGAGATGTTATGGC
L2CNAG_07580 5' flanking region primer 2TCACTGGCCGTCGTTTTACATAGAGGACTTGGAGGTGGG
R1CNAG_07580 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGGCAATGCTGTGAATCTTGTG
R2CNAG_07580 3' flanking region primer 2AGAGTAGGGCTGAGCAAGAC
SOCNAG_07580 diagnostic screening primer, pairing with B79TGGAAAGACCTGTTGCGAC
POCNAG_07580 Southern blot probe primerTCTTCGGGAAATGGACTG
STMNAT#102 STM primerCCATAGCGATATCTACCCCAATCT
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_07580T0
Mating Data
Growth phenotype for CNAG_07580T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_07580T0
Urease
Urease phenotype for CNAG_07580T0
Melanin
Melanin phenotype for CNAG_07580T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_07580T0
Oxidative Stress
Oxidative stress phenotype for CNAG_07580T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_07580T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_07580T0
ER Stress
ER stress phenotype for CNAG_07580T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_07580T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_07580T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_07580T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_07580T0