Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_03137T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationCMGC/CDK protein kinase
Gene SymbolPHO8501
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNG04270 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
CMGC-23.50.000000000000025
Microbial Kinome Result
PredictionScoreE-value
ePK107.77.1e-33
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K02206 KEGG 1.7e-45 153.7
Amino Acid SequenceMDRRRLVIGQGRHGAVIAQPAPSDPAIWDRRSRPNASDTSQWGATPLGGLEGWQAVKIVSAPPDGRLRSMLPHDVGEEVKILKRLDHSNIVKLVDYHYETDLLEHYLHFPLFACTLTELFKDPSFPFEPPAIPLPQPSPLASFNVTTGLSYQLLTALGYLASSDVAHRDINPSNLLIDFCGNLKLVDFGTAWSGSSAVMMDNQGETVVRHDRSANGREQSQGDGEGVRARSSCDVGTGAYRAPELLFSPVKYNPYAVDSWAAGCVIAQMFRPFGSFDPHEFDDSGSDSDSDIRSDSEEGSDGWSDNTEDPDPLDEPWRRVRNSGGDGNGTGSRTGTTTGGDKGGMGERQPMFDASFGTLGLAASIFKIRGTPSLDTWPTFIQLPDAGKIGFPSSHPIPLTSPLILPHLQEGHDELMAAASKVIEGLLTLDPGRRLTAKKALESRWFEGVDNVLVQGVCRPWVDVGKKSLERKIQSV
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 831
B YPD 30°C, concentration: 5x10^7 cells/ml 633
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 675
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 772
E YPD 37°C, concentration: 5x10^7 cells/ml 958
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 1001
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_03137 5' flanking region primer 1CAAGGAGGTCAACCCTACAG
L2CNAG_03137 5' flanking region primer 2TCACTGGCCGTCGTTTTACAGGCGTCTTCTGTCCATAG
R1CNAG_03137 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGAGTCGTCCTCTTTTTGTGC
R2CNAG_03137 3' flanking region primer 2AGGACTTGTCGGTCTTCAG
SOCNAG_03137 diagnostic screening primer, pairing with B79GGTAAGTTGCTTTATCCCCC
POCNAG_03137 Southern blot probe primerGCTGTGAGCAGTTGATACG
STMNAT#273 STM primerGAGATCTTTCGGGAGGTCTGGATT
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_03137T0
Mating Data
Growth phenotype for CNAG_03137T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_03137T0
Urease
Urease phenotype for CNAG_03137T0
Melanin
Melanin phenotype for CNAG_03137T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_03137T0
Oxidative Stress
Oxidative stress phenotype for CNAG_03137T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_03137T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_03137T0
ER Stress
ER stress phenotype for CNAG_03137T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_03137T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_03137T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_03137T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_03137T0